BDBM50242374 CHEMBL505529::topostatin

SMILES CCCCCCCC(C)CC=C(C)C=CC(=O)C(C)CCC1OC(=O)[C@H](CC(OS(O)(=O)=O)C(N)=O)NC(=O)[C@@H](C)CNC(=O)C(=C)NC(=O)C1C

InChI Key InChIKey=XLDIAUNLPWGNHO-KNNFRUAVSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50242374   

TargetDNA topoisomerase(Bos taurus)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(CHEMBL505529 | topostatin)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition calf thymus gland topoisomerase 1 assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(CHEMBL505529 | topostatin)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of telomerase from human COLO201 cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Cercopithecus aethiops)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(CHEMBL505529 | topostatin)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition topoisomerase 1 in african green monkey Vero cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(CHEMBL505529 | topostatin)
Affinity DataIC50:  5.50E+4nMAssay Description:Inhibition topoisomerase 1 in human A549 cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(CHEMBL505529 | topostatin)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition topoisomerase 1 in human COLO201 cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(CHEMBL505529 | topostatin)
Affinity DataIC50:  2.90E+4nMAssay Description:Inhibition topoisomerase 1 in human HeLa cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(CHEMBL505529 | topostatin)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition human placenta topoisomerase 2 assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(CHEMBL505529 | topostatin)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition human placenta topoisomerase 2 assessed as conversion of catenated kinetoplast DNA to minicircle monomerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRibonuclease pancreatic(Bison bison (American bison))
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(CHEMBL505529 | topostatin)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of bovine pancreas RNase A assessed as undigested supercoiled pBR322 DNA concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyribonuclease-1(Bos taurus)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(CHEMBL505529 | topostatin)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of bovine pancreas DNase 1 assessed as undigested supercoiled pBR322 DNA concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyribonuclease-2-alpha(Sus scrofa)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(CHEMBL505529 | topostatin)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of porcine spleen DNase 2 assessed as undigested supercoiled pBR322 DNA concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA ligase(Bacteriophage T4)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(CHEMBL505529 | topostatin)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of T4 ligase from bacteriophage infected Escherichia coli assessed as ligation of supercoiled pBR322 DNAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType II restriction enzyme BamHI(Bacillus amyloliquefaciens)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(CHEMBL505529 | topostatin)
Affinity DataIC50:  1.85E+5nMAssay Description:Inhibition of Bacillus amyloliquifaction Bam H1 assessed as undigested supercoiled pBR322 DNA concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType II restriction enzyme EcoRI(Escherichia coli)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(CHEMBL505529 | topostatin)
Affinity DataIC50: >2.50E+5nMAssay Description:Inhibition of Escherichia coli Eco R1 assessed as undigested supercoiled pBR322 DNA concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType II restriction enzyme HindIII(Haemophilus influenzae)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(CHEMBL505529 | topostatin)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of Haemophilus influenzae Hind 3 assessed as undigested supercoiled pBR322 DNA concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType II restriction enzyme PstI(Providencia stuartii)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(CHEMBL505529 | topostatin)
Affinity DataIC50:  1.90E+4nMAssay Description:Inhibition of Providencia stuartii Pst 1 assessed as undigested supercoiled pBR322 DNA concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType II restriction enzyme ScaI(Streptomyces caespitosus)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(CHEMBL505529 | topostatin)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of Streptomyces caespitosus Sca 1 assessed as undigested supercoiled pBR322 DNA concentrationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 1(Mus musculus)
Kumamoto University

Curated by ChEMBL
LigandPNGBDBM50242374(CHEMBL505529 | topostatin)
Affinity DataIC50:  4.70E+4nMAssay Description:Inhibition topoisomerase 1 in mouse NIH/3T3 cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed