BDBM50242374 CHEMBL505529::topostatin

SMILES CCCCCCCC(C)CC=C(C)C=CC(=O)C(C)CCC1OC(=O)[C@H](CC(OS(O)(=O)=O)C(N)=O)NC(=O)[C@@H](C)CNC(=O)C(=C)NC(=O)C1C

InChI Key InChIKey=XLDIAUNLPWGNHO-UHFFFAOYSA-N

Data  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50242374   

TargetDNA topoisomerase 1(Green monkey)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50242374BDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition topoisomerase 1 in african green monkey Vero cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50242374BDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition topoisomerase 1 in human HeLa cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Mouse)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50242374BDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 4.70E+4nMAssay Description:Inhibition topoisomerase 1 in mouse NIH/3T3 cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50242374BDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition topoisomerase 1 in human COLO201 cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetDNA topoisomerase 1(Human)
Kumamoto University

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50242374BDBM50242374(topostatin | CHEMBL505529)
Affinity DataIC50: 5.50E+4nMAssay Description:Inhibition topoisomerase 1 in human A549 cells assessed as conversion of supercoiled pBR322 DNA to relaxed formMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed