BDBM50248045 (S)-1-(2-fluorophenyl)ethyl (S)-quinuclidin-3-ylcarbamate::CHEMBL499536

SMILES C[C@H](OC(=O)N[C@@H]1CN2CCC1CC2)c1ccccc1F

InChI Key InChIKey=HQYLURGLNKLOQJ-UHFFFAOYSA-N

Data  8 IC50  2 Kd  5 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50248045   

LigandPNGBDBM50248045((S)-1-(2-fluorophenyl)ethyl (S)-quinuclidin-3-ylca...)
Affinity DataKd:  200nMAssay Description:Displacement of [125I]alpha-bungarotoxin from human recombinant alpha7 nAchRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50248045((S)-1-(2-fluorophenyl)ethyl (S)-quinuclidin-3-ylca...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in human GH3 cells by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50248045((S)-1-(2-fluorophenyl)ethyl (S)-quinuclidin-3-ylca...)
Affinity DataEC50:  100nMAssay Description:Agonist activity at human recombinant alpha7 nAChR expressed in human GH3 cells by calcium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50248045((S)-1-(2-fluorophenyl)ethyl (S)-quinuclidin-3-ylca...)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as induction of inward currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
LigandPNGBDBM50248045((S)-1-(2-fluorophenyl)ethyl (S)-quinuclidin-3-ylca...)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at human alpha7 nAChR expressed in Xenopus oocytes assessed as induction of inward currentMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 3A(Human)
Targacept

Curated by ChEMBL
LigandPNGBDBM50248045((S)-1-(2-fluorophenyl)ethyl (S)-quinuclidin-3-ylca...)
Affinity DataKd:  1.30E+4nMAssay Description:Binding affinity to 5HT3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed