BDBM50257525 CHEMBL4091370

SMILES COc1ccc(CNc2ccc(cc2F)-c2ccn3c(CC4CC4)nnc3c2C(F)(F)F)cn1

InChI Key InChIKey=ZXOJYKOGKAXEMM-UHFFFAOYSA-N

Data  1 KI  1 Kd  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50257525   

TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50257525(CHEMBL4091370)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50257525(CHEMBL4091370)
Affinity DataKd:  2.90nMAssay Description:Positive allosteric modulation of human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes assessed as increase in glutamate-induced...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Leiden University

Curated by ChEMBL
LigandPNGBDBM50257525(CHEMBL4091370)
Affinity DataEC50:  5.90nMAssay Description:Displacement of [3H]-JNJ46281222 from human metabotropic glutamate receptor 2 expressed in CHOK1 cell membranes after 60 mins by microbeta counting a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed