BDBM50262684 CHEMBL514232::N-(1,1'-biphenyl-2-ylmethyl)-N',N'-dimethyl-N-[(3S)-pyrrolidin-3-yl]sulfamide

SMILES CN(C)S(=O)(=O)N(Cc1ccccc1-c1ccccc1)[C@H]1CCNC1

InChI Key InChIKey=WSUKOKAEFHVCAH-SFHVURJKSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50262684   

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262684(CHEMBL514232 | N-(1,1'-biphenyl-2-ylmethyl)-N',N'-...)
Affinity DataKi:  8nMAssay Description:Inhibition of [3H]nisoxetine reuptake at human NET expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262684(CHEMBL514232 | N-(1,1'-biphenyl-2-ylmethyl)-N',N'-...)
Affinity DataKi:  2.69E+3nMAssay Description:Inhibition of [3H]dopamine reuptake at human DAT expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262684(CHEMBL514232 | N-(1,1'-biphenyl-2-ylmethyl)-N',N'-...)
Affinity DataKi:  3.33E+3nMAssay Description:Inhibition of [3H]citalopram uptake at human 5HTT expressed in HEK293 cells by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50262684(CHEMBL514232 | N-(1,1'-biphenyl-2-ylmethyl)-N',N'-...)
Affinity DataIC50:  840nMAssay Description:Inhibition of CYP2D6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed