BDBM50267632 4-(3-Hydroxy-2-methoxy-benzoyl)-1-(2-p-fluorophenylethyl)-piperidine::CHEMBL489624

SMILES COc1c(O)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1

InChI Key InChIKey=QSNQXCLTDBTOIU-UHFFFAOYSA-N

Data  1 KI  8 IC50  6 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50267632   

Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Institute Of Nuclear Chemistry Johannes Gutenberg-University Mainz

Curated by ChEMBL
LigandPNGBDBM50267632(4-(3-Hydroxy-2-methoxy-benzoyl)-1-(2-p-fluoropheny...)
Affinity DataKi:  1.34nMAssay Description:Displacement of [3H]MDL from rat 5HT2A receptor expressed in GF62 cells by liquid scintillation analyserMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50267632(4-(3-Hydroxy-2-methoxy-benzoyl)-1-(2-p-fluoropheny...)
Affinity DataIC50:  23nMAssay Description:Antagonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as inhibition of glutamate-induced intracellu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50267632(4-(3-Hydroxy-2-methoxy-benzoyl)-1-(2-p-fluoropheny...)
Affinity DataIC50:  22nMAssay Description:Antagonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as inhibition of 5HT-induced intracellular Ca...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50267632(4-(3-Hydroxy-2-methoxy-benzoyl)-1-(2-p-fluoropheny...)
Affinity DataIC50:  22nMAssay Description:Antagonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as inhibition of 5HT-induced intracellular Ca...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50267632(4-(3-Hydroxy-2-methoxy-benzoyl)-1-(2-p-fluoropheny...)
Affinity DataIC50:  9.20nMAssay Description:Antagonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization inc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50267632(4-(3-Hydroxy-2-methoxy-benzoyl)-1-(2-p-fluoropheny...)
Affinity DataIC50:  9.10nMAssay Description:Antagonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization inc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50267632(4-(3-Hydroxy-2-methoxy-benzoyl)-1-(2-p-fluoropheny...)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity at human mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as increase in intracellular Ca2+ mobilization incubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50267632(4-(3-Hydroxy-2-methoxy-benzoyl)-1-(2-p-fluoropheny...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at human mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as increase in intracellular Ca2+ mobilization incubat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50267632(4-(3-Hydroxy-2-methoxy-benzoyl)-1-(2-p-fluoropheny...)
Affinity DataEC50: >5.00E+4nMAssay Description:Positive modulator activity at human mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as increase in intracellular Ca2+ mobilizat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50267632(4-(3-Hydroxy-2-methoxy-benzoyl)-1-(2-p-fluoropheny...)
Affinity DataEC50: <5.01E+4nMAssay Description:Positive modulator activity at human mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as increase in intracellular Ca2+ mobilizat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50267632(4-(3-Hydroxy-2-methoxy-benzoyl)-1-(2-p-fluoropheny...)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50267632(4-(3-Hydroxy-2-methoxy-benzoyl)-1-(2-p-fluoropheny...)
Affinity DataIC50:  11nMAssay Description:Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50267632(4-(3-Hydroxy-2-methoxy-benzoyl)-1-(2-p-fluoropheny...)
Affinity DataEC50: >5.00E+4nMAssay Description:Agonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as increase in intracellular Ca2+ mobilization i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50267632(4-(3-Hydroxy-2-methoxy-benzoyl)-1-(2-p-fluoropheny...)
Affinity DataEC50: <5.01E+4nMAssay Description:Agonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as increase in intracellular Ca2+ mobilization i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50267632(4-(3-Hydroxy-2-methoxy-benzoyl)-1-(2-p-fluoropheny...)
Affinity DataIC50:  23nMAssay Description:Antagonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as inhibition of glutamate-induced intracellu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed