BDBM50278316 CHEMBL450079::sodium pyrophosphate(V)

SMILES [O-]P([O-])(=O)OP([O-])([O-])=O

InChI Key InChIKey=XPPKVPWEQAFLFU-UHFFFAOYSA-J

Data  36 KI  1 IC50

PDB links: 138 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 37 hits for monomerid = 50278316   

TargetAlpha-carbonic anhydrase(Helicobacter pylori (strain G27))
Universit£

LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  6.60E+5nM ΔG°:  -4.26kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of Vibrio cholerae alpha carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-carbonic anhydrase(Helicobacter pylori)
Universit?? Degli Studi Di Firenze

LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  6.60E+5nM ΔG°:  -4.34kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity Khalifah RG. The carbon dioxide hy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 13(Mus musculus (mouse))
Universit£

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  7.30E+5nMAssay Description:Inhibition of mouse recombinant carbonic anhydrase 13-catalyzed CO2 hydration by stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Helicobacter pylori)
Universit?? Degli Studi Di Firenze

LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  7.50E+5nM ΔG°:  -4.26kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA catalysed CO2 hydration activity Khalifah RG. The carbon dioxide hy...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 7(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  8.70E+5nMAssay Description:Inhibition of human recombinant carbonic anhydrase 7-catalyzed CO2 hydration by stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 4(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  1.01E+6nMAssay Description:Inhibition of human recombinant carbonic anhydrase 4-catalyzed CO2 hydration by stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Vibrio cholerae serotype O1 (strain ATCC 39315 / E...)
Universit£

LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  2.96E+6nM ΔG°:  -3.39kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of Flaveria bidentis carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma carbonic anhydrase family protein(Vibrio cholerae)
Universit£

LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  7.30E+6nM ΔG°:  -2.86kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of Vibrio cholerae recombinant carbonic anhydrase gamma expressed in Escherichia coli DE3 cells preincubated for 15 mins by stopped-flow C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 /...)
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  8.20E+6nMpH: 8.3Assay Description:Inhibition of Pseudomonas aeruginosa PAO1 type-2 beta-carbonic anhydrase psCA3 expressed in Escherichia coli Tuner BL21 (DE3) cells pre-incubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Vibrio cholerae)
Universit£

LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  1.51E+7nM ΔG°:  -2.44kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of Vibrio cholerae carbonic anhydrase beta preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Istituto Di Bioscienze E Biorisorse (Ibbr)-Cnr

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  2.58E+7nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Istituto Di Bioscienze E Biorisorse (Ibbr)-Cnr

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  2.58E+7nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Istituto Di Bioscienze E Biorisorse (Ibbr)-Cnr

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  2.58E+7nMAssay Description:Inhibition of human carbonic anhydrase-1 at 20 degC preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Istituto Di Bioscienze E Biorisorse (Ibbr)-Cnr

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  2.58E+7nMAssay Description:Inhibition of human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Istituto Di Bioscienze E Biorisorse (Ibbr)-Cnr

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  2.58E+7nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1-catalyzed CO2 hydration by stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Istituto Di Bioscienze E Biorisorse (Ibbr)-Cnr

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  2.58E+7nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Istituto Di Bioscienze E Biorisorse (Ibbr)-Cnr

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  2.58E+7nMpH: 8.3Assay Description:Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay at pH 8.3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Istituto Di Bioscienze E Biorisorse (Ibbr)-Cnr

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  2.58E+7nMAssay Description:Inhibition of human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Istituto Di Bioscienze E Biorisorse (Ibbr)-Cnr

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  2.58E+7nM ΔG°:  -2.13kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  4.85E+7nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  4.85E+7nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  4.85E+7nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  4.85E+7nMAssay Description:Inhibition of human cytosolic carbonic anhydrase-2 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  4.85E+7nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 assessed as inhibition of CO2 hydration incubated for 15 mins prior to testing by stopped flow C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  4.85E+7nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  4.85E+7nMAssay Description:Inhibition of human CA2 after 15 mins by stopped-flow/Co2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  4.85E+7nMAssay Description:Inhibition of human CA2 incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  4.85E+7nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2-catalyzed CO2 hydration by stopped flow assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  4.85E+7nM ΔG°:  -1.76kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition of Helicobacter pylori alpha carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  4.85E+7nMAssay Description:Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  4.85E+7nMpH: 8.3Assay Description:Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay at pH 8.3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  4.85E+7nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  4.85E+7nMAssay Description:Inhibition of human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  4.85E+7nMAssay Description:Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  4.85E+7nMAssay Description:Inhibition of Pseudomonas aeruginosa PAO1 type-2 beta-carbonic anhydrase psCA3 expressed in Escherichia coli Tuner BL21 (DE3) cells pre-incubated for...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase(Astrosclera willeyana)
Slovak Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataKi:  5.77E+7nMAssay Description:Inhibition of Astrosclera willeyana recombinant GST-tagged astrosclerin 3 expressed in Escherichia coli BL21-DE3-RIPL cells preincubated for 15 mins ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetButyrophilin subfamily 3 member A1(Homo sapiens (Human))
Western Michigan University

Curated by ChEMBL
LigandPNGBDBM50278316(CHEMBL450079 | sodium pyrophosphate(V))
Affinity DataIC50:  1.14E+6nMAssay Description:Displacement of GDP-BODIPY from C-terminal 6His-tagged BTN3A1 B30.2 domain (unknown origin) expressed in Escherichia coli BL21 (DE) measured after 60...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed