BDBM50288373 CHEMBL4175808
SMILES [H][C@]12CN(c3cnc(F)c(Nc4ncc(C)c(N[C@H](C)C(C)C)n4)c3)[C@]([H])(CN1C)C2
InChI Key InChIKey=GFUUFEUYGAMCSI-PVAVHDDUSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50288373
Affinity DataIC50: 26nMAssay Description:Inhibition of cytoplasmic recombinant human GST-tagged JAK1 (886 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 1.81E+4nMAssay Description:Inhibition of recombinant human JAK3 (781 to 1124 residues) expressed in insect cells using 5FAM-GEEPLYWSFPAKKK-NH2 as substrate after 10 mins by cal...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of recombinant human JAK2 (831 to 1132 residues) expressed in insect cells using 5FAM-GEEPLYWSFPAKKK-NH2 as substrate after 10 mins by cal...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged TYK2 (871 to 1187 residues) expressed in baculovirus expression system using 5FAM-GEEPLYWSFPAKK...More data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Inhibition of JAK1 in human NCI-H1975 cells assessed as reduction in STAT3 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair