BDBM50293013 CHEMBL455275::Methyl 4-((4-(2-(6,7-dimethoxy-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl)phenyl)aminocarbonyl)-2-(quinoline-6-carbonylamino)benzoate

SMILES COC(=O)c1ccc(cc1NC(=O)c1ccc2ncccc2c1)C(=O)Nc1ccc(CCN2CCc3cc(OC)c(OC)cc3C2)cc1

InChI Key InChIKey=WDTJXSRPRRUIIV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50293013   

TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Universidad Nacional De Colombia

Curated by ChEMBL
LigandPNGBDBM50293013(CHEMBL455275 | Methyl 4-((4-(2-(6,7-dimethoxy-1,2,...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ABCB1 expressed in Kb-V1 cells after 10 mins by calcein-AM assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50293013(CHEMBL455275 | Methyl 4-((4-(2-(6,7-dimethoxy-1,2,...)
Affinity DataIC50:  179nMAssay Description:Inhibition of ABCG2 overexpressed in human MCF7/Topo cells by flow cytometric-based mitoxantrone efflux assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
University Of Regensburg

Curated by ChEMBL
LigandPNGBDBM50293013(CHEMBL455275 | Methyl 4-((4-(2-(6,7-dimethoxy-1,2,...)
Affinity DataIC50:  172nMAssay Description:Inhibition of ABCG2 expressed in human MCF7/Topo cells by Hoechst microplate assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed