BDBM50294744 3-Benzyl-8-chloro-4-(3-{[2-chloro-3-(trifluoromethyl)-benzyl]oxy}phenyl)cinnoline::CHEMBL550983

SMILES FC(F)(F)c1cccc(COc2cccc(c2)-c2c(Cc3ccccc3)nnc3c(Cl)cccc23)c1Cl

InChI Key InChIKey=ZTRCQAWKQLDVDC-UHFFFAOYSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50294744   

TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294744(3-Benzyl-8-chloro-4-(3-{[2-chloro-3-(trifluorometh...)
Affinity DataIC50:  2.40E+4nMAssay Description:Displacement of [3H]T0901317 from human recombinant N-terminal biotinylated tagged LXRbeta ligand binding domain (154-461) expressed in Escherichia c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294744(3-Benzyl-8-chloro-4-(3-{[2-chloro-3-(trifluorometh...)
Affinity DataIC50:  8.37E+5nMAssay Description:Agonist activity at human LXRalpha ligand binding domain (205-448) expressed in human HuH7 cells co-transfected with Gal4-DBD by luciferase transacti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294744(3-Benzyl-8-chloro-4-(3-{[2-chloro-3-(trifluorometh...)
Affinity DataEC50:  1.53E+4nMAssay Description:Agonist activity at human LXRalpha ligand binding domain (205-448) expressed in human HuH7 cells cotransfected with Gal4-DBD by luciferase transactiv...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50294744(3-Benzyl-8-chloro-4-(3-{[2-chloro-3-(trifluorometh...)
Affinity DataEC50:  6.54E+3nMAssay Description:Agonist activity at human LXRbeta ligand binding domain (219-462) expressed in human HuH7 cells cotransfected with Gal4-DBD by luciferase transactiva...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed