BDBM50300028 CHEMBL569864::N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine
SMILES COc1cc2nc(nc(NC3CCN(Cc4ccccc4)CC3)c2cc1OC)N1CCCN(C)CC1
InChI Key InChIKey=OSXFATOLZGZLSK-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 48 hits for monomerid = 50300028
Affinity DataIC50: 3.83E+3nMAssay Description:Inhibition of human G9a expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 67nMAssay Description:Inhibition of G9a (unknown origin) using [histone H3 1 to 25 residues] and SAM substrate by scintillation proximity assayMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of human G9a using core histone H3 as substrate incubated for 1 hr in presence of [3H]-SAM by filter binding methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of recombinant human G9a (685 to 1000 residues) using H3 peptide (1 to 20 residues) by mass spectrometryMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of recombinant human GLP (610 to 917 residues) using H3 peptide (1 to 20 residues) by mass spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of G9a (685 to 1000 residues) (unknown origin) expressed in Escherichia coli BL21More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of DNMT1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of GST-fused G9a (amino acids 685 to 1000) (unknown origin) expressed in Escherichia coli BL21 by DELFIA assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of GST-fused GLP (amino acids 610 to 917) (unknown origin) expressed in Escherichia coli BL21 by DELFIA assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of G9a (unknown origin) using H3(1-20)-cys as substrate by HPLC analysisMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of GLP (unknown origin) using H3(1-20)-cys as substrate by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.56E+3nMAssay Description:Inhibition of G9a in human MDA-MB-231 cells assessed as reduction in H3K9me2 level after 2 days by immunofluorescence in-cell western analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of human NSD2 SET domain (948 to 1239 residues)-mediated mono-methylation activity assessed as reduction in H3K36me1 level incubated for 1...More data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of human recombinant G9a methylation activity expressed in Escherichia coli assessed as effect on H3K9 level by cell based assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of GLP (unknown origin)More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase, H3 lysine-36 specific(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 1.12E+5nMAssay Description:Inhibition of human recombinant NSD1 (5475 to 6345 residues) expressed in Escherichia coli BL21 (DE3) incubated for 4 hrs by scintillation/filter ass...More data for this Ligand-Target Pair
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of human recombinant NSD2 (2844 to 3717 residues) expressed in Escherichia coli BL21 (DE3) incubated for 4 hrs by scintillation/filter ass...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase NSD3(Human)
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
University of Texas Medical Branch (UTMB)
Curated by ChEMBL
Affinity DataIC50: 9.50E+4nMAssay Description:Inhibition of human recombinant NSD3 (3084 to 3954 residues) expressed in Escherichia coli BL21 (DE3) incubated for 4 hrs by scintillation/filter ass...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant G9a (785 to 1210 residues) expressed in baculovirus-infected Sf9 cells using biotinylated histo...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of GST-tagged full length human G9a (685 to 1000 residues) methylation activity expressed in Escherichia coli BL21 assessed as reduction i...More data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of human LSD1 (unknown orgin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of G9a (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of recombinant G9aMore data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Inhibition of G9a by Alpha screen assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
TargetHistone-lysine N-methyltransferase EHMT1(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Activity at methyl transferase activity GLP by enzyme coupled S-adenocylehomocystein detection assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 27nMAssay Description:Activity at methyl transferase activity GLP by chemiluminescence based oxygen tunneling assayMore data for this Ligand-Target Pair
Affinity DataKd: 130nMAssay Description:Binding affinity to G9a by isothermal titration colorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of methyl transferase activity of G9a assessed as inhibition of H3K9 methylation by chemiluminescence based oxygen tunneling assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of G9a (685 to 1000) (unknown origin) assessed as H3K9me2 level by mass spectrophotometric analysisMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of GLP (610 to 917) (unknown origin) assessed as H3K9me2 level by mass spectrophotometric analysisMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of N-terminal hexahistidine-tagged SET domain of human GLP (951 to 1235) expressed in Escherichia coli BL21 (DE3) using Histone H3 peptide...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of N-terminal hexahistidine-tagged SET domain of human G9a (913 to 1193) expressed in Escherichia coli BL21 (DE3) using Histone H3 peptide...More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of G9a by Alpha screen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of G9aMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of Histone H3 lysine 9 of GLP methyltransferaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+5nMAssay Description:Activity at methyl transferase activity G9a by enzyme coupled S-adenocylehomocystein detection assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of lysine methyltransferase G9aMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human N-terminal hexahistidine-tagged G9a SET domain amino acid 913 to 1193 expressed in Escherichia coli BL21 (DE3) using Histone H3 p...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of human N-terminal hexahistidine-tagged GLP SET domain amino acid 951 to 1235 expressed in Escherichia coli BL21 (DE3) using Histone H3 p...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of N-terminal hexahistidine-tagged human G9a (913 to 1193 residues) expressed in Escherichia coli BL21 (DE3)-Gold cells using histone H3 (...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of GST-tagged G9a (685 to 1000 residues) (unknown origin) expressed in Escherichia coli BL21 using biotinylated H3 (1to20 residues) as sub...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase EHMT1(Human)
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
The University of Texas M.D. Anderson Cancer Center
Curated by ChEMBL
Affinity DataIC50: 700nMAssay Description:Inhibition of EHMT1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human DNMT1 using polydeoxyinosine polydeoxycytosine DNA as substrate after 15 mins in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human G9a using biotinylated-H3K9 peptide as substrate after 1 hr in presence of SAM by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of G9a (unknown origin) by mas spectrometric methodMore data for this Ligand-Target Pair