BDBM50301375 3,3',5,5'-tetraiodo-L-thyronine::3,5,3',5'-tetraiodo-L-thyronine::4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodo-L-phenylalanine::CHEMBL1624::L-T4::L-thyroxine::O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine::levothyroxine

SMILES N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C(O)=O

InChI Key InChIKey=XUIIKFGFIJCVMT-LBPRGKRZSA-N

Data  9 IC50  2 Kd  6 EC50

PDB links: 26 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50301375   

TargetTransthyretin(Homo sapiens (Human))
Universitat De Barcelona

Curated by ChEMBL

LigandBDBM50301375(3,3',5,5'-tetraiodo-L-thyronine | 3,5,3',5'-tetrai...)Copy SMILESCopy InChI

Affinity DataIC50:  1.05E+4nMAssay Description:Inhibition of TTR mediated fibrillogenesis assessed as acid-induced protein aggregation turbidity after 1.5 hrs by turbidimetric assayMore data for this Ligand-Target Pair

Target InfoPDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseChEBI
CHEMBLDrugBankMCE
KEGGMMDBPC cidPC sidPDBPatentsSimilars

In DepthDetails ArticlePubMedDrugBank
PDB3D Structure (crystal)
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