BDBM50302429 2-(9-(2-hydroxy-2-methylpropyl)-6-(isopentyloxy)-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile::CHEMBL567696

SMILES CC(C)CCOc1ccc2c3[nH]c(nc3c3ccc(CC(C)(C)O)cc3c2c1)-c1c(cccc1C#N)C#N

InChI Key InChIKey=NFIWTFUHOYGDPB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50302429   

TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50302429(2-(9-(2-hydroxy-2-methylpropyl)-6-(isopentyloxy)-1...)
Affinity DataIC50:  0.400nMAssay Description:Displacement of [3H]PGH2 from human recombinant PGES1 expressed in CHOK1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50302429(2-(9-(2-hydroxy-2-methylpropyl)-6-(isopentyloxy)-1...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of mPGES-1 in IL-1beta-stimulated human A549 cell microsomal membranes assessed as reduction in PGE2 formation incubated for 15 mins using...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed