BDBM50314776 CHEMBL1089865::N-Cyclopropyl-3-(1-(2,6-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-5-yl)-4-methylbenzamide

SMILES Cc1ccc(cc1-c1cc2cnn(-c3c(F)cccc3F)c2n(C)c1=O)C(=O)NC1CC1

InChI Key InChIKey=BTFCCPKDGZFGPR-UHFFFAOYSA-N

Data  4 KI  8 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50314776   

TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataKi:  1.40nMAssay Description:Inhibition of human recombinant p38alpha-mediated AFT2 phosphorylation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of p38betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataKi:  2.10E+3nMAssay Description:Inhibition of p38deltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 12(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataKi:  3.50E+3nMAssay Description:Inhibition of p38gammaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataIC50:  3.60E+4nMAssay Description:Inhibition of human ERG by electrophysiology assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of LPS-induced MK2 phosphorylation in human whole blood treated 30 mins before LPS challenge measured after 45 mins by FACS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to RAF1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataKd:  1.10E+3nMAssay Description:Binding affinity to PDGFRalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of P38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataKd:  0.25nMAssay Description:Binding affinity to p38alpha by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50314776(CHEMBL1089865 | N-Cyclopropyl-3-(1-(2,6-difluoroph...)
Affinity DataKd:  0.670nMAssay Description:Binding affinity to p38betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed