BDBM50316303 ((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl hydrogen diphosphate::CHEMBL1094974

SMILES C[n+]1cn([C@@H]2O[C@H](COP([O-])(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)c2nc(N)[nH]c(=O)c12

InChI Key InChIKey=SBASPRRECYVBRF-UHFFFAOYSA-N

Data  1 KI  2 IC50  3 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50316303   

TargetEukaryotic translation initiation factor 4E(Mouse)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50316303(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataKd:  45nMAssay Description:Binding affinity to mouse eIF4E expressed in Escherichia coli by fluorescence time-synchronized titration method in presence of KKRYDREFLLGFQFIFAMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Targetm7GpppX diphosphatase(Human)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50316303(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human DCPS using m7GMPF as substrate after 30 mins by nucleoside 5'-fluorophosphate probe based HTS assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50316303(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataKd:  49nMAssay Description:Binding affinity to murine eIF4E assessed as intrinsic fluorescence quenching of tryptophan residues by fluorescence spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Mouse)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50316303(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataKd:  70nMAssay Description:Displacement of pyrene-labeled 7-methylguanosine-pentaphosphate probe from murine eIF4E assessed as decrease in fluorescence intensity incubated for ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetEukaryotic translation initiation factor 4E(Rabbit)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50316303(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of eIF4E in rabbit reticulocyte lysate system assessed as reduction in ARCA mRNA cap-dependent translation measured after 60 mins by lucif...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Targetm7GpppX diphosphatase(Human)
University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50316303(((2R,3S,4R,5R)-5-(2-amino-7-methyl-6-oxo-1H-purin-...)
Affinity DataKi:  680nMAssay Description:Inhibition of human DcpS using pyrene labeled 7-methylguanosine triphosphate as substrate preincubated for 15 mins followed by enzyme addition by flu...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed