BDBM50318189 (Z)-2-(3-((7-(2-Methoxyphenyl)-9-oxo-5H-benzo[h]thiazolo[2,3-b]-quinazolin-10(6H,7H,9H)-ylidene)methyl)phenoxy)acetic Acid::CHEMBL1097075

SMILES COc1ccccc1C1C2=C(N=c3s\c(=C/c4cccc(OCC(O)=O)c4)c(=O)n13)c1ccccc1CC2

InChI Key InChIKey=XCPQKGPAGJNOBL-XYGWBWBKSA-N

Data  4 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50318189   

TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50318189((Z)-2-(3-((7-(2-Methoxyphenyl)-9-oxo-5H-benzo[h]th...)
Affinity DataIC50:  3.10E+3nMAssay Description:Displacement of FITC labeled BH3 peptide from His-tagged human BCL2 after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 homolog(Mus musculus (Mouse))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50318189((Z)-2-(3-((7-(2-Methoxyphenyl)-9-oxo-5H-benzo[h]th...)
Affinity DataIC50:  6.40E+3nMAssay Description:Displacement of FITC-labeled BH3 peptide from GST-tagged mouse Mcl1 after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50318189((Z)-2-(3-((7-(2-Methoxyphenyl)-9-oxo-5H-benzo[h]th...)
Affinity DataKd:  9.50E+3nMAssay Description:Binding affinity to human Bcl-XL by surface plasma resonance based biosensor systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50318189((Z)-2-(3-((7-(2-Methoxyphenyl)-9-oxo-5H-benzo[h]th...)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of human Bcl-XLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50318189((Z)-2-(3-((7-(2-Methoxyphenyl)-9-oxo-5H-benzo[h]th...)
Affinity DataIC50:  3.40E+3nMAssay Description:Displacement of FITC-labeled BH3 peptide from human Bcl-XL after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed