BDBM50320067 1-(4-amino-2-((ethylamino)methyl)-1H-imidazo[4,5-c]quinolin-1-yl)-2-methylpropan-2-ol::CHEMBL1085742::US10457681, Compound Gardiquimod::US10487084, Compound Gardiquimod::US10508115, Compound Gardiquimod::US10919895, Gardiquimod::US10981914, Compound Gardiquimod

SMILES CCNCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)O

InChI Key InChIKey=FHJATBIERQTCTN-UHFFFAOYSA-N

Data  9 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50320067   

TargetToll-like receptor 7(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50320067(1-(4-amino-2-((ethylamino)methyl)-1H-imidazo[4,5-c...)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at human TLR7 expressed in NFkappaB-stimulated HEK293 cells assessed as induction of secreted alkaline phosphatase expression by rep...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetToll-like receptor 7(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50320067(1-(4-amino-2-((ethylamino)methyl)-1H-imidazo[4,5-c...)
Affinity DataEC50:  3.34E+3nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) r...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetToll-like receptor 7(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50320067(1-(4-amino-2-((ethylamino)methyl)-1H-imidazo[4,5-c...)
Affinity DataEC50:  172nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) r...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetToll-like receptor 7(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50320067(1-(4-amino-2-((ethylamino)methyl)-1H-imidazo[4,5-c...)
Affinity DataEC50:  3.34E+3nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetToll-like receptor 7(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50320067(1-(4-amino-2-((ethylamino)methyl)-1H-imidazo[4,5-c...)
Affinity DataEC50:  8.60nMAssay Description:Agonist activity at human TLR7 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetToll-like receptor 7(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50320067(1-(4-amino-2-((ethylamino)methyl)-1H-imidazo[4,5-c...)
Affinity DataEC50:  3.34E+3nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)

TargetToll-like receptor 7(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50320067(1-(4-amino-2-((ethylamino)methyl)-1H-imidazo[4,5-c...)
Affinity DataEC50:  2.00E+3nMAssay Description:Agonist activity at TLR7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetToll-like receptor 7(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50320067(1-(4-amino-2-((ethylamino)methyl)-1H-imidazo[4,5-c...)
Affinity DataEC50:  4.00E+3nMAssay Description:Agonist activity at human TLR7 in HEK-Blue hTLR7 cells incubated for 18 hrs by QUANTI-Blue reagent based SEAP reporter assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedPDB3D3D Structure (crystal)

TargetToll-like receptor 7(Human)
University of Kansas

Curated by ChEMBL
LigandPNGBDBM50320067(1-(4-amino-2-((ethylamino)methyl)-1H-imidazo[4,5-c...)
Affinity DataEC50:  3.34E+3nMAssay Description:Engineered human embryonic kidney blue cells (HEK-Blue™ TLR cells; Invivogen) possessing a human TLR7-secreted embryonic alkaline phosphatase (SEAP) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
PDB3D3D Structure (crystal)