BDBM50320336 (R)-(4-(4-(4-(hydroxymethyl)phenyl)phthalazin-1-yl)-3-methylpiperazin-1-yl)(phenyl)methanone::CHEMBL1084734

SMILES C[C@@H]1CN(CCN1c1nnc(-c2ccc(CO)cc2)c2ccccc12)C(=O)c1ccccc1

InChI Key InChIKey=DRVZFOGEZROJQL-LJQANCHMSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50320336   

TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50320336((R)-(4-(4-(4-(hydroxymethyl)phenyl)phthalazin-1-yl...)
Affinity DataIC50:  2.70nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50320336((R)-(4-(4-(4-(hydroxymethyl)phenyl)phthalazin-1-yl...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed