BDBM50322467 2-(4,6-Bis(4-methylphenethoxy)pyrimidin-2-ylthio)-hexanoic acid::CHEMBL1173376
SMILES CCCCC(Sc1nc(OCCc2ccc(C)cc2)cc(OCCc2ccc(C)cc2)n1)C(O)=O
InChI Key InChIKey=BUCFYPOIQPKROS-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50322467
TargetPeroxisome proliferator-activated receptor gamma(Human)
Zafes/Liff/Goethe University Frankfurt
Curated by ChEMBL
Zafes/Liff/Goethe University Frankfurt
Curated by ChEMBL
Affinity DataEC50: 7.50E+3nMAssay Description:Agonist activity at human PPARgamma-LBD expressed in COS7 cells co-transfected with Gal4 by luciferase based transactivation assayMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt
Curated by ChEMBL
Zafes/Liff/Goethe University Frankfurt
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of 5-lipoxygenase-mediated 5(S)-H(p)ETE formation in fMLP-stimulated human PMNL incubated 10 mins prior to fMLP challengeMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Zafes/Liff/Goethe University Frankfurt
Curated by ChEMBL
Zafes/Liff/Goethe University Frankfurt
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human recombinant 5-lipoxygenase-mediated product formation from arachidonic acid after 5 to 10 mins by HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibition of mPGES-1 in human IL-1beta-stimulated A549 cell microsomes assessed as reduction of PGE2 formation from PGH2 after 15 mins by RP-HPLC an...More data for this Ligand-Target Pair