BDBM50326992 CHEMBL471737::ivabradine

SMILES COc1cc2C[C@H](CN(C)CCCN3CCc4cc(OC)c(OC)cc4CC3=O)c2cc1OC

InChI Key InChIKey=ACRHBAYQBXXRTO-OAQYLSRUSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50326992   

TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1(Mus musculus)
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)

Curated by ChEMBL
LigandPNGBDBM50326992(CHEMBL471737 | ivabradine)
Affinity DataEC50:  4.50E+3nMAssay Description:Blockade of mouse HCN1 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4(Homo sapiens (Human))
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)

Curated by ChEMBL
LigandPNGBDBM50326992(CHEMBL471737 | ivabradine)
Affinity DataEC50:  4.28E+3nMAssay Description:Blockade of human HCN4 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2(Mus musculus)
Laboratory Of Design, Synthesis, And Study Of Biologically Active Heterocycles (Heterobiolab)

Curated by ChEMBL
LigandPNGBDBM50326992(CHEMBL471737 | ivabradine)
Affinity DataEC50:  4.52E+3nMAssay Description:Blockade of mouse HCN2 expressed in HEK293 cells at -120 f-current amplitude by patch-clamp electrophysiological assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed