BDBM50327157 (R)-methyl 2-(3,4-dichlorophenyl)-2-((R)-piperidin-2-yl)acetate::CHEMBL1179011

SMILES COC(=O)[C@@H]([C@H]1CCCCN1)c1ccc(Cl)c(Cl)c1

InChI Key InChIKey=JUKMAYKVHWKRKY-CHWSQXEVSA-N

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50327157   

TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50327157((R)-methyl 2-(3,4-dichlorophenyl)-2-((R)-piperidin...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]WIN-35,428 from human DAT expressed in mouse N2A cells after 15 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50327157((R)-methyl 2-(3,4-dichlorophenyl)-2-((R)-piperidin...)
Affinity DataIC50:  2.70nMAssay Description:Potency of inhibiting 10 pM [125I]-RTI-55 binding to dopamine receptor in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
State University Of New York

Curated by ChEMBL
LigandPNGBDBM50327157((R)-methyl 2-(3,4-dichlorophenyl)-2-((R)-piperidin...)
Affinity DataIC50:  5.30nMAssay Description:Potency of inhibiting 10 pM [125I]-RTI-55 binding to dopamine transporter in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Rattus norvegicus (rat))
Institute Of Technology

Curated by ChEMBL
LigandPNGBDBM50327157((R)-methyl 2-(3,4-dichlorophenyl)-2-((R)-piperidin...)
Affinity DataIC50:  5.30nMAssay Description:Displacement of [3H]WIN 35428 from Sprague-Dawley rat striatal tissue after 2 hrs by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed