BDBM50327535 2-(4-bromophenyl)-N-((2-(thiophen-3-yl)-7-(trifluoromethoxy)quinolin-3-yl)methyl)ethanamine::CHEMBL1257380

SMILES FC(F)(F)Oc1ccc2cc(CNCCc3ccc(Br)cc3)c(nc2c1)-c1ccsc1

InChI Key InChIKey=COABNJKRUFUDCE-UHFFFAOYSA-N

Data  2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50327535   

TargetG-protein coupled bile acid receptor 1(Mus musculus)
Kalypsys Inc

Curated by ChEMBL
LigandPNGBDBM50327535(2-(4-bromophenyl)-N-((2-(thiophen-3-yl)-7-(trifluo...)
Show SMILES FC(F)(F)Oc1ccc2cc(CNCCc3ccc(Br)cc3)c(nc2c1)-c1ccsc1
Show InChI InChI=1S/C23H18BrF3N2OS/c24-19-4-1-15(2-5-19)7-9-28-13-18-11-16-3-6-20(30-23(25,26)27)12-21(16)29-22(18)17-8-10-31-14-17/h1-6,8,10-12,14,28H,7,9,13H2
Affinity DataIC50: 1.00E+4nMAssay Description:Agonist activity at mouse TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Kalypsys Inc

Curated by ChEMBL
LigandPNGBDBM50327535(2-(4-bromophenyl)-N-((2-(thiophen-3-yl)-7-(trifluo...)
Show SMILES FC(F)(F)Oc1ccc2cc(CNCCc3ccc(Br)cc3)c(nc2c1)-c1ccsc1
Show InChI InChI=1S/C23H18BrF3N2OS/c24-19-4-1-15(2-5-19)7-9-28-13-18-11-16-3-6-20(30-23(25,26)27)12-21(16)29-22(18)17-8-10-31-14-17/h1-6,8,10-12,14,28H,7,9,13H2
Affinity DataIC50: 1.00E+4nMAssay Description:Agonist activity at human TGR5 receptor expressed in HEK293 cells assessed as intracellular cAMP levelMore data for this Ligand-Target Pair