BDBM50331095 CHEMBL1289494::Tivozanib::US10464902, Tivozanib

SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC

InChI Key InChIKey=SPMVMDHWKHCIDT-UHFFFAOYSA-N

Data  1 KI  20 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50331095   

TargetFibroblast growth factor 2(Homo sapiens (Human))
Nanjing University

LigandPNGBDBM50331095(CHEMBL1289494 | Tivozanib | US10464902, Tivozanib)
Affinity DataIC50:  114nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Nanjing University

LigandPNGBDBM50331095(CHEMBL1289494 | Tivozanib | US10464902, Tivozanib)
Affinity DataIC50:  42.4nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Nanjing University

LigandPNGBDBM50331095(CHEMBL1289494 | Tivozanib | US10464902, Tivozanib)
Affinity DataIC50:  3.38nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Nanjing University

LigandPNGBDBM50331095(CHEMBL1289494 | Tivozanib | US10464902, Tivozanib)
Affinity DataIC50:  124nMpH: 7.2 T: 2°CAssay Description:VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed