BDBM50340098 5-(4-hydroxy-3-methoxybenzylidene)-2-thioxothiazolidin-4-one::CHEMBL255822

SMILES COc1cc(C=C2SC(S)=NC2=O)ccc1O

InChI Key InChIKey=OWXPWWRBBBGOLO-UHFFFAOYSA-N

Data  1 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50340098   

TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50340098(5-(4-hydroxy-3-methoxybenzylidene)-2-thioxothiazol...)
Affinity DataKi:  74nMAssay Description:Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50340098(5-(4-hydroxy-3-methoxybenzylidene)-2-thioxothiazol...)
Affinity DataIC50:  1.73E+3nMAssay Description:Displacement of [3H]-rosiglitazone from human recombinant C-terminal His-tagged cytosolic domain of mitoNEET (32-108) by scintillation proximity assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCDGSH iron-sulfur domain-containing protein 1(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50340098(5-(4-hydroxy-3-methoxybenzylidene)-2-thioxothiazol...)
Affinity DataIC50:  1.73E+3nMAssay Description:Displacement of [3H]rosiglitazone from recombinant human C-terminal His-tagged MitoNEET cytosolic domain (32 to 108 residues) expressed in Escherichi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Northeastern Ohio Universities Colleges Of Medicine And Pharmacy

Curated by ChEMBL
LigandPNGBDBM50340098(5-(4-hydroxy-3-methoxybenzylidene)-2-thioxothiazol...)
Affinity DataIC50:  2.86E+4nMAssay Description:Inhibition of human recombinant MAOA assessed as inhibition of kynuramine conversion to fluorescent metabolite 4-hydroxyquinoline by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Shaoyang University

Curated by ChEMBL
LigandPNGBDBM50340098(5-(4-hydroxy-3-methoxybenzylidene)-2-thioxothiazol...)
Affinity DataIC50:  1.11E+7nMAssay Description:Inhibition of diphenolase activity of mushroom tyrosinase preincubated with compound for 10 mins before addition of L-DOPA as substrate by spectropho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
Northeastern Ohio Universities Colleges Of Medicine And Pharmacy

Curated by ChEMBL
LigandPNGBDBM50340098(5-(4-hydroxy-3-methoxybenzylidene)-2-thioxothiazol...)
Affinity DataIC50:  2.49E+3nMAssay Description:Inhibition of human recombinant MAOB by amplex red assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed