BDBM50342601 CHEMBL1255901::Huperzine A

SMILES C\C=C1/[C@@H]2Cc3[nH]c(=O)ccc3[C@]1(N)CC(C)=C2

InChI Key InChIKey=ZRJBHWIHUMBLCN-UHFFFAOYSA-N

Data  6 KI  17 IC50  2 Koff  3 Kon

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50342601   

TargetAcetylcholinesterase(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataIC50: 114nMAssay Description:Inhibition of rat AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataIC50: 44.5nMAssay Description:Compound was tested for its ability to inhibit the action of acetylcholinesterase isolated from rat brain cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Kieler Wirkstoff-Zentrum (Kiwiz) At The Helmholtz-Zenrum F�R Ozeanforschung Geomar

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataIC50: 12nMAssay Description:Inhibition of human AChE pre-incubated for 10 mins before acetylthiocholine iodide substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetAcetylcholinesterase(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataKoff:  0.0567s-1Assay Description:Kinetic constant for inhibition of fetal bovine serum acetylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetAcetylcholinesterase(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataKoff:  0.0570s-1Assay Description:Kinetic constant for inhibition of fetal bovine serum acetylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetAcetylcholinesterase(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataKon:  0.000333M-1s-1Assay Description:Kinetic constant for inhibition of fetal bovine serum acetylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetAcetylcholinesterase(Mouse)
Ume£

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataIC50: 82nMAssay Description:Inhibition of mouse AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataIC50: 80nMAssay Description:In vitro inhibitory activity against Acetylcholinesterase (AChE) using rat brain hippocampal crude homogenates.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetCholinesterase(Human)
Alchemical Research

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataIC50: 100nMAssay Description:Inhibition of BChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Kieler Wirkstoff-Zentrum (Kiwiz) At The Helmholtz-Zenrum F�R Ozeanforschung Geomar

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataIC50: 5nMAssay Description:Inhibition of AChE-induced amyloid beta aggregationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2011
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Kieler Wirkstoff-Zentrum (Kiwiz) At The Helmholtz-Zenrum F�R Ozeanforschung Geomar

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataIC50: 5nMAssay Description:Inhibition of AChE (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Kieler Wirkstoff-Zentrum (Kiwiz) At The Helmholtz-Zenrum F�R Ozeanforschung Geomar

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of acetylcholinesterase (unknown origin) assessed as inhibition of acetylcholine hydrolysis after 30 mins by Ellmann's methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/8/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataIC50: 114nMAssay Description:Inhibitory potency against acetylcholinesterase (AChE) of rat cortex homogenate with ethopropazine as BChE inhibitorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataIC50: 80nMAssay Description:Acetylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetCarboxylic ester hydrolase(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataIC50: 1.00E+6nMAssay Description:The compound was tested for Butyrylcholinesterase inhibitory activity in rat striatal homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataIC50: 45nMAssay Description:Compound was tested for its ability to inhibit the action of acetylcholinesterase isolated from rat brain cortexMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataIC50: 94nMAssay Description:Inhibitory activity against acetylcholinesterase in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetAcetylcholinesterase(Human)
Kieler Wirkstoff-Zentrum (Kiwiz) At The Helmholtz-Zenrum F�R Ozeanforschung Geomar

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataIC50: 150nMAssay Description:Inhibitory activity against acetylcholinesterase in human RBCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetAcetylcholinesterase(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataKon:  0.000367M-1s-1 Koff:  0.0155s-1Assay Description:Dissociation constant for the inhibition of fetal bovine serum acetylcholinesterase was determined..More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetAcetylcholinesterase(Human)
Kieler Wirkstoff-Zentrum (Kiwiz) At The Helmholtz-Zenrum F�R Ozeanforschung Geomar

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataIC50: 5nMAssay Description:In vitro inhibitory activity against Acetylcholinesterase (AChE).More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/26/2012
Entry Details Article

TargetCarboxylic ester hydrolase(Rat)
Hoechst-Roussel Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataIC50: 1.35E+5nMAssay Description:Inhibitory potency against rat serum Butyrylcholinesterase with BW284c51 as AChE inhibitorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataKi:  5.90nMAssay Description:Dissociation constant for the inhibition of fetal bovine serum acetylcholinesterase was determined..More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetAcetylcholinesterase(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataKi:  5.90nMAssay Description:Dissociation constant for the inhibition of fetal bovine serum acetylcholinesterase was determined..More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/27/2012
Entry Details Article

TargetAcetylcholinesterase(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataKi:  5.90nMAssay Description:Binding affinity towards Acetylcholinesterase from fetal bovine serumMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Bovine)
TBA

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataKi:  24nMAssay Description:Inhibitory constant against fetal bovine serum (FBS) acetylcholinesteraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Rat)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataKi:  24nMAssay Description:Compound was tested for its ability to inhibit acetylcholinesterase (AChE) in rat brain; 0.024-0.040 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2012
Entry Details Article
PubMed
TargetAcetylcholinesterase(Pacific electric ray)
University of Siena

Curated by ChEMBL
LigandPNGBDBM50342601(Huperzine A | CHEMBL1255901)
Affinity DataKi:  175nMAssay Description:Inhibition of Torpedo californica AChEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/16/2012
Entry Details Article
PubMed