BDBM50344991 2-(4'-(ethylsulfonyl)-2'-methyl-5-(trifluoromethyl)biphenyl-2-yloxy)acetic acid::CHEMBL1778639

SMILES CCS(=O)(=O)c1ccc(c(C)c1)-c1cc(ccc1OCC(O)=O)C(F)(F)F

InChI Key InChIKey=KDOSMMYSHYZFQE-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50344991   

TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344991(2-(4'-(ethylsulfonyl)-2'-methyl-5-(trifluoromethyl...)
Affinity DataIC50:  29nMAssay Description:Antagonist activity at human CRTh2 receptor expressed in CHO cells assessed as inhibition of PGD2-induced calcium flux in presence of 1% bovine serum...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344991(2-(4'-(ethylsulfonyl)-2'-methyl-5-(trifluoromethyl...)
Affinity DataIC50:  0.900nMAssay Description:Displacement of [3H]-PGD2 from CRTh2 receptor by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Cavia porcellus)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344991(2-(4'-(ethylsulfonyl)-2'-methyl-5-(trifluoromethyl...)
Affinity DataIC50:  63nMAssay Description:Binding affinity to guinea pig CRTh2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Rattus norvegicus)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344991(2-(4'-(ethylsulfonyl)-2'-methyl-5-(trifluoromethyl...)
Affinity DataIC50:  1.30nMAssay Description:Binding affinity to rat CRTh2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344991(2-(4'-(ethylsulfonyl)-2'-methyl-5-(trifluoromethyl...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344991(2-(4'-(ethylsulfonyl)-2'-methyl-5-(trifluoromethyl...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344991(2-(4'-(ethylsulfonyl)-2'-methyl-5-(trifluoromethyl...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344991(2-(4'-(ethylsulfonyl)-2'-methyl-5-(trifluoromethyl...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344991(2-(4'-(ethylsulfonyl)-2'-methyl-5-(trifluoromethyl...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin D2 receptor 2(Mus musculus (mouse))
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50344991(2-(4'-(ethylsulfonyl)-2'-methyl-5-(trifluoromethyl...)
Affinity DataIC50:  1nMAssay Description:Binding affinity to mouse CRTh2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed