BDBM50345250 5-bromo-7-(piperidin-4-ylmethylamino)benzofuran-2-carboxylic acid::CHEMBL1782521

SMILES OC(=O)c1cc2cc(Br)cc(NCC3CCNCC3)c2o1

InChI Key InChIKey=JPSRNNAKSXAWPL-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50345250   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345250(5-bromo-7-(piperidin-4-ylmethylamino)benzofuran-2-...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345250(5-bromo-7-(piperidin-4-ylmethylamino)benzofuran-2-...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345250(5-bromo-7-(piperidin-4-ylmethylamino)benzofuran-2-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345250(5-bromo-7-(piperidin-4-ylmethylamino)benzofuran-2-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345250(5-bromo-7-(piperidin-4-ylmethylamino)benzofuran-2-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345250(5-bromo-7-(piperidin-4-ylmethylamino)benzofuran-2-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345250(5-bromo-7-(piperidin-4-ylmethylamino)benzofuran-2-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed