BDBM50345259 CHEMBL1782530::cis-7-(4-aminocyclohexylamino)-5-bromobenzofuran-2-carboxylic acid

SMILES N[C@H]1CC[C@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O

InChI Key InChIKey=BLBAWGODFTZAEY-PHIMTYICSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50345259   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345259(CHEMBL1782530 | cis-7-(4-aminocyclohexylamino)-5-b...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345259(CHEMBL1782530 | cis-7-(4-aminocyclohexylamino)-5-b...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345259(CHEMBL1782530 | cis-7-(4-aminocyclohexylamino)-5-b...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345259(CHEMBL1782530 | cis-7-(4-aminocyclohexylamino)-5-b...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant PIM1 in presence of ATP by ELISA based spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345259(CHEMBL1782530 | cis-7-(4-aminocyclohexylamino)-5-b...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345259(CHEMBL1782530 | cis-7-(4-aminocyclohexylamino)-5-b...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345259(CHEMBL1782530 | cis-7-(4-aminocyclohexylamino)-5-b...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Genzyme

Curated by ChEMBL
LigandPNGBDBM50345259(CHEMBL1782530 | cis-7-(4-aminocyclohexylamino)-5-b...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed