BDBM50348228 CHEMBL1800807

SMILES COc1cc(F)c(cc1-c1ccc(cc1CN1[C@@H](C)[C@H](OC1=O)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(F)(F)F)C(C)C

InChI Key InChIKey=MZZLGJHLQGUVPN-HAWMADMCSA-N

Data  13 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50348228   

TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50348228(CHEMBL1800807)
Affinity DataIC50:  60nMAssay Description:Inhibition of full-length human recombinant CETP expressed in CHO cells by BODIPY-CE dye based fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50348228(CHEMBL1800807)
Affinity DataIC50:  17.2nMAssay Description:Inhibition of human recombinant CETP-mediated cholesteryl ester transfer activity after 1 hr by fluorescent cholesteryl esters transfer assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50348228(CHEMBL1800807)
Affinity DataIC50:  17.2nMAssay Description:Inhibition of CETP-mediated neutral lipid transfer by fluorometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50348228(CHEMBL1800807)
Affinity DataIC50:  46nMAssay Description:Inhibition of CETP in human plasma assessed as reduction in fluorescent intensity by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50348228(CHEMBL1800807)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant CETP (unknown origin) assessed as inhibition of BODIPY-labeled cholesteryl transfer to fluorescent substrate by fluorimetri...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50348228(CHEMBL1800807)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant full length human CETP expressed in CHO cells assessed as reduction in BODIPY-CE transfer measured after 1 to 3 hrs by fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM50348228(CHEMBL1800807)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of [S35]-MK-0499 binding to human ERG expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50348228(CHEMBL1800807)
Affinity DataIC50:  18nMAssay Description:Inhibition of CETP in human plasma measured every 30 mins for 120 mins by fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50348228(CHEMBL1800807)
Affinity DataIC50:  36nMAssay Description:Inhibition of human CETPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50348228(CHEMBL1800807)
Affinity DataIC50:  53nMAssay Description:Inhibition of CETP in 95% human serum assessed as inhibition of transfer of [3H] cholesteryl oleate or [3H] triolein between LDL and HDLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50348228(CHEMBL1800807)
Affinity DataIC50:  45nMAssay Description:Inhibition of recombinant CETP (unknown origin) assessed as inhibition of transfer of [3H]cholesteryl oleate or [3H]triolein between exogenous [3H]LD...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50348228(CHEMBL1800807)
Affinity DataIC50:  17nMAssay Description:Inhibition of recombinant CETP (unknown origin) assessed as inhibition of transfer of [3H]cholesteryl oleate or [3H]triolein using exogenous LDL and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Shenyang Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50348228(CHEMBL1800807)
Affinity DataIC50:  34nMAssay Description:Inhibition of recombinant human CETP after 3 hrs using fluorescent cholesteryl containing HDL after 3 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed