BDBM50353747 CHEMBL561013::JWH-018

SMILES CCCCCn1cc(C(=O)c2cccc3ccccc23)c2ccccc12

InChI Key InChIKey=JDNLPKCAXICMBW-UHFFFAOYSA-N

Data  18 KI  1 IC50  2 Kd  9 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 30 hits for monomerid = 50353747   

TargetCannabinoid receptor 1(Mus musculus (Mouse))
University of Arkansas for Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]CP-55,940 from CB1 receptor in B6SJL mouse brain membrane after 90 mins by liquid scintillation spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]-CP55940 from human CB1 receptor expressed in human HEK293-EBNA cells incubated for 60 mins by radioligand competitive binding as...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]-CP55940 from human CB1 receptor expressed in human HEK293-EBNA cells incubated for 60 mins by radioligand competitive binding as...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]-CP55940 from human CB2 receptor expressed in CHO cells incubated for 90 mins by liquid scintillation spectrophotometry relative ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataKi:  2.90nMAssay Description:Binding affinity to CB2 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))
Biological Research Centre of the Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]WIN-55,212-2 from CB1R/CB2R in Wistar rat brain membranes after 60 mins by liquid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataKi:  2.90nMAssay Description:Displacement of [3H]CP-55940 from human cloned CB2 receptor by filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))
Biological Research Centre of the Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]JWH-018 from CB1R/CB2R in Wistar rat brain membranes after 60 mins by liquid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataKi:  4.30nMAssay Description:Displacement of [3H]-CP55940 from human CB1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataKi:  9nMAssay Description:Displacement of [3H]-CP55940 from human CB1 receptor expressed in CHO cells incubated for 90 mins by liquid scintillation spectrophotometry relative ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Universidade Federal do Rio de Janeiro

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataKi:  9.02nMAssay Description:Displacement of [3H]CP-55940 from CB1 receptor in rat brain by filtration assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataKi:  9.5nMAssay Description:Displacement of [3H]-CP55940 from N-terminal 3HA-tagged human CB2 receptor expressed in human HEK293-EBNA cells incubated for 60 mins by radioligand ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataKi:  9.5nMAssay Description:Binding affinity to CB1 receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataKi:  9.60nMAssay Description:Displacement of [3H]-CP55940 from N-terminal 3HA-tagged human CB2 receptor expressed in human HEK293-EBNA cells incubated for 60 mins by radioligand ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetFatty acid-binding protein, liver(Mus musculus (Mouse))
Avanti Polar Lipids

LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataKi:  58nMAssay Description:The following fluorescent ligand displacement assays at 24 °C were used to further confirm and/or determine if the cytosolic lipidic ligand "chaperon...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Biological Research Centre of the Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]Ile5,6-deltorphin-2 from DOR in Wistar rat brain membranes after 60 mins by liquid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Biological Research Centre of the Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]DAMGO from MOR in Wistar rat brain membranes after 60 mins by liquid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Biological Research Centre of the Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]HS-665 from KOR in guinea pig brain membranes after 60 mins by liquid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))
Biological Research Centre of the Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataKd:  6.5nMAssay Description:Displacement of [3H]JWH-018 from CB1R/CB2R in Wistar rat brain membranes assessed as dissociation rate constant at 10 uM by liquid scintillation anal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))
Biological Research Centre of the Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataKd:  3.40nMAssay Description:Displacement of [3H]JWH-018 from CB1R/CB2R in Wistar rat brain membranes assessed as dissociation constant by liquid scintillation analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1/2(Rattus norvegicus (Rat))
Biological Research Centre of the Hungarian Academy of Sciences

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataEC50:  36nMAssay Description:Agonist activity at CB1R/CB2R in Wistar rat brain membranes after 60 mins by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Rattus norvegicus (rat))
Universidade Federal do Rio de Janeiro

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataIC50:  280nMAssay Description:Activation of CB1 receptor in Wistar rat prelimbic prefrontal cortex assessed as reduction of field excitatory postsynaptic potential amplitude after...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human CB1 receptor expressed in mouse AtT20 cells incubated for 60 mins by FLIPR membrane potential assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataEC50:  7.30nMAssay Description:Agonist activity at CB2 receptor (unknown origin) expressed in human HEK293T cells co-expressing beta-arrestin2 assessed as beta-arrestin2 recruitmen...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human CB2 receptor expressed in mouse AtT20 cells incubated for 60 mins by FLIPR membrane potential assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human CB2 receptor expressed in mouse AtT20 cells incubated for 60 mins by FLIPR membrane potential assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataEC50:  35nMAssay Description:Agonist activity at CB1 receptor (unknown origin) expressed in human HEK293T cells co-expressing beta-arrestin2 assessed as beta-arrestin2 recruitmen...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataEC50:  36nMAssay Description:Agonist activity at CB1 receptor (unknown origin) expressed in human HEK293T cells co-expressing beta-arrestin2 assessed as beta-arrestin2 recruitmen...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
West Virginia University

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataEC50:  7.20nMAssay Description:Agonist activity at CB2 receptor (unknown origin) expressed in human HEK293T cells co-expressing beta-arrestin2 assessed as beta-arrestin2 recruitmen...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50353747(CHEMBL561013 | JWH-018)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human CB1 receptor expressed in mouse AtT20 cells incubated for 60 mins by FLIPR membrane potential assayMore data for this Ligand-Target Pair
In DepthDetails PubMed