BDBM50359501 CHEMBL1927024::HYDROXYAMPHETAMINE

SMILES C[C@H](N)Cc1ccc(O)cc1

InChI Key InChIKey=GIKNHHRFLCDOEU-ZETCQYMHSA-N

Data  1 IC50  1 Kd  5 EC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50359501   

TargetBeta-secretase 1(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50359501(CHEMBL1927024 | HYDROXYAMPHETAMINE)
Show SMILES C[C@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C9H13NO/c1-7(10)6-8-2-4-9(11)5-3-8/h2-5,7,11H,6,10H2,1H3/t7-/m0/s1
Affinity DataKd:  8.00E+5nMAssay Description:Binding affinity to BACE1 by surface plasmon resonance methodMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
F. Hoffmann-La Roche Inc

Curated by ChEMBL
LigandPNGBDBM50359501(CHEMBL1927024 | HYDROXYAMPHETAMINE)
Show SMILES C[C@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C9H13NO/c1-7(10)6-8-2-4-9(11)5-3-8/h2-5,7,11H,6,10H2,1H3/t7-/m0/s1
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Homo sapiens (Human))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50359501(CHEMBL1927024 | HYDROXYAMPHETAMINE)
Show SMILES C[C@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C9H13NO/c1-7(10)6-8-2-4-9(11)5-3-8/h2-5,7,11H,6,10H2,1H3/t7-/m0/s1
Affinity DataEC50:  2.96E+3nMAssay Description:Activation of C-terminal HA epitope tagged human TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein, Galpha16 by cAMP accumulation assayMore data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Macaca mulatta)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50359501(CHEMBL1927024 | HYDROXYAMPHETAMINE)
Show SMILES C[C@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C9H13NO/c1-7(10)6-8-2-4-9(11)5-3-8/h2-5,7,11H,6,10H2,1H3/t7-/m0/s1
Affinity DataEC50:  101nMAssay Description:Activation of rhesus monkey TAAR1 expressed in RD-HGA16 cells co-expressing Gq protein assessed as cAMP accumulation by fluorescence plate readerMore data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50359501(CHEMBL1927024 | HYDROXYAMPHETAMINE)
Show SMILES C[C@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C9H13NO/c1-7(10)6-8-2-4-9(11)5-3-8/h2-5,7,11H,6,10H2,1H3/t7-/m0/s1
Affinity DataEC50:  50nMAssay Description:Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by competitive binding assayMore data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Mus musculus (Mouse))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50359501(CHEMBL1927024 | HYDROXYAMPHETAMINE)
Show SMILES C[C@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C9H13NO/c1-7(10)6-8-2-4-9(11)5-3-8/h2-5,7,11H,6,10H2,1H3/t7-/m0/s1
Affinity DataEC50:  280nMAssay Description:Activation of mouse TAAR1 expressed in human HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
TargetTrace amine-associated receptor 1(Rattus norvegicus (Rat))
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50359501(CHEMBL1927024 | HYDROXYAMPHETAMINE)
Show SMILES C[C@H](N)Cc1ccc(O)cc1
Show InChI InChI=1S/C9H13NO/c1-7(10)6-8-2-4-9(11)5-3-8/h2-5,7,11H,6,10H2,1H3/t7-/m0/s1
Affinity DataEC50:  190nMAssay Description:Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair