BDBM50362690 AMG-837::CHEMBL1829173

SMILES CC#C[C@@H](CC(O)=O)c1ccc(OCc2cccc(c2)-c2ccc(cc2)C(F)(F)F)cc1

InChI Key InChIKey=ZOPNBMMVVZRSGH-NRFANRHFSA-N

Data  2 KI  1 IC50  1 Kd  22 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50362690   

TargetFree fatty acid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362690(AMG-837 | CHEMBL1829173)
Affinity DataEC50:  8.80E+3nMAssay Description:Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 100% human seru...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362690(AMG-837 | CHEMBL1829173)
Affinity DataEC50:  80nMAssay Description:Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysis in presence of 0.01% human ser...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362690(AMG-837 | CHEMBL1829173)
Affinity DataEC50:  13nMAssay Description:Partial agonist activity at human GPR40 expressed in CHO cells measured over 20 secs interval by luminometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Rattus norvegicus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50362690(AMG-837 | CHEMBL1829173)
Affinity DataEC50:  23nMAssay Description:Agonist activity at rat GPR40More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Mus musculus)
Amgen

Curated by ChEMBL
LigandPNGBDBM50362690(AMG-837 | CHEMBL1829173)
Affinity DataEC50:  13nMAssay Description:Agonist activity at mouse GPR40More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362690(AMG-837 | CHEMBL1829173)
Affinity DataEC50:  25nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells assessed as calcium flux measured for 20 secs by aequorin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362690(AMG-837 | CHEMBL1829173)
Affinity DataEC50:  60nMAssay Description:Agonist activity at human FFA1 receptor expressed in CHO cell membranes after 4 hrs by aequorin bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362690(AMG-837 | CHEMBL1829173)
Affinity DataEC50:  104nMAssay Description:Agonist activity at human GPR40 expressed in CHO cells by aequorin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50362690(AMG-837 | CHEMBL1829173)
Affinity DataEC50:  41nMAssay Description:Agonist activity at human GPR40 expressed in mouse A9 cells by inositol phosphate accumulation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed