BDBM50363645 DEBROMOHYMENIALDISINE

SMILES NC1=NC(C(=O)N1)=C1CCNC(=O)c2[nH]ccc12

InChI Key InChIKey=JYRJOQGKGMHTOO-UHFFFAOYSA-N

Data  8 IC50

PDB links: 4 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50363645   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50363645(DEBROMOHYMENIALDISINE)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of Chk1Checked by AuthorMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50363645(DEBROMOHYMENIALDISINE)
Affinity DataIC50:  725nMAssay Description:Inhibition of human CHK1 using STK1 as substrate after 10 mins by HTRF assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Michigan State University

Curated by ChEMBL
LigandPNGBDBM50363645(DEBROMOHYMENIALDISINE)
Affinity DataIC50:  183nMAssay Description:Inhibition of human Chk2 using STK1 as substrate after 10 mins by HTRF assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50363645(DEBROMOHYMENIALDISINE)
Affinity DataIC50:  725nMAssay Description:Inhibition of CHK1 (unknown origin) using polypeptide substrate after 40 mins in presence of [gamma-33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50363645(DEBROMOHYMENIALDISINE)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of MEK1 phosphorylation by activated human recombinant RafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Michigan State University

Curated by ChEMBL
LigandPNGBDBM50363645(DEBROMOHYMENIALDISINE)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of Chk2Checked by AuthorMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Michigan State University

Curated by ChEMBL
LigandPNGBDBM50363645(DEBROMOHYMENIALDISINE)
Affinity DataIC50:  183nMAssay Description:Inhibition of CHK2 (unknown origin) using polypeptide substrate after 40 mins in presence of [gamma-33P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 1(Homo sapiens (Human))
University Of Utah

Curated by ChEMBL
LigandPNGBDBM50363645(DEBROMOHYMENIALDISINE)
Affinity DataIC50:  824nMAssay Description:Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed