BDBM50365225 CHEMBL1956290::US9238653, Table 5, Compound 14

SMILES Cc1cc(Nc2ccc(cc2)C(F)(F)F)n2nc(nc2n1)C(F)(F)F

InChI Key InChIKey=OFUZRRSLIRZBNG-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50365225   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum (isolate 3D7))
Board Of Regents, The University Of Texas System

US Patent
LigandPNGBDBM50365225(CHEMBL1956290 | US9238653, Table 5, Compound 14)
Affinity DataIC50:  35nMpH: 8.0Assay Description:For studying inhibition of Plasmodium or human DHODH enzyme, two assays that are in routine use are described, for example, in Baldwin, et al. (2002)...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Rattus norvegicus (rat))
University Of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50365225(CHEMBL1956290 | US9238653, Table 5, Compound 14)
Affinity DataIC50:  3.50E+3nMAssay Description:Inhibition of rat DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroorot...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365225(CHEMBL1956290 | US9238653, Table 5, Compound 14)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human C-terminal hexa-His tagged DHODH expressed in Escherichia coli by DCIP reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50365225(CHEMBL1956290 | US9238653, Table 5, Compound 14)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of C-terminal His6-tagged human DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid pro...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Mus musculus)
University Of Texas At Dallas

Curated by ChEMBL
LigandPNGBDBM50365225(CHEMBL1956290 | US9238653, Table 5, Compound 14)
Affinity DataIC50:  9.70E+3nMAssay Description:Inhibition of mouse DHODH (amino acid residues 30 to 396) expressed in Escherichia coli BL21 cells assessed as orotic acid production using dihydroor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed