BDBM50380313 CHEMBL1234354::US8633204, 286

SMILES COc1ccc(cn1)-c1cc2c(C)nc(N)nc2n([C@H]2CC[C@@H](CC2)OCCO)c1=O

InChI Key InChIKey=XDLYKKIQACFMJG-WKILWMFISA-N

Data  8 KI  7 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50380313   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Pkucare Pharmaceutical R & D Center

Curated by ChEMBL
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of mTOR (unknown origin) assessed as inhibition of 4EBP-1 phosphorylation preincubated for 15 mins before substrate addition by TR-FRET as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Pkucare Pharmaceutical R & D Center

Curated by ChEMBL
LigandPNGBDBM50380313(CHEMBL1234354 | US8633204, 286)
Affinity DataIC50:  8.30nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2/PS as substrate preincubated for 15 mins before substrate addition by luciferase-based luminescen...More data for this Ligand-Target Pair