BDBM50383274 CHEMBL1229592::US10167264, WZ4002::US9670213, WZ4002
SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)C=C)c2)n1)N1CCN(C)CC1
InChI Key InChIKey=ITTRLTNMFYIYPA-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50383274
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Haiyan Pharmaceutical Technology Co. Itd.
Curated by ChEMBL
Shanghai Haiyan Pharmaceutical Technology Co. Itd.
Curated by ChEMBL
Affinity DataIC50: 46nMAssay Description:Inhibition of EGFR L858R/T790M mutant phosphorylation in human NCI-H1975 cells after 1 hr by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Haiyan Pharmaceutical Technology Co. Itd.
Curated by ChEMBL
Shanghai Haiyan Pharmaceutical Technology Co. Itd.
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of recombinant human GST-tagged wild-type EGFR cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression system using ...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Haiyan Pharmaceutical Technology Co. Itd.
Curated by ChEMBL
Shanghai Haiyan Pharmaceutical Technology Co. Itd.
Curated by ChEMBL
Affinity DataIC50: 710nMAssay Description:Inhibition of wild-type EGFR phosphorylation in human A431 cells preincubated for 1 hr followed by EGF stimulation measured after 45 mins by ELISAMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Haiyan Pharmaceutical Technology Co. Itd.
Curated by ChEMBL
Shanghai Haiyan Pharmaceutical Technology Co. Itd.
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human GST-tagged EGFR L858R/T790M mutant cytoplasmic domain (668 to 1210 residues) expressed in baculovirus expression syst...More data for this Ligand-Target Pair