BDBM50392776 CHEMBL2151151

SMILES CC(=O)N[C@@H](Cc1ccccc1)[C@H](O)CN[C@H]1CC2(CCC2)Oc2ncc(CC(C)(C)C)cc12

InChI Key InChIKey=PSUGQZDSIJNGJX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50392776   

TargetCathepsin D(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50392776(CHEMBL2151151)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of Cathepsin D (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50392776(CHEMBL2151151)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of BACE by cells based assayMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50392776(CHEMBL2151151)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of BACEMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50392776(CHEMBL2151151)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant BACE1 using Glu-Ile-Asp-Leu-Met-Val-Leu-Asp as substrate incubated for 60 mins prior to substrate addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetBeta-secretase 1(Human)
TBA

Curated by ChEMBL
LigandPNGBDBM50392776(CHEMBL2151151)
Affinity DataIC50: 3nMAssay Description:Inhibition of BACE1 in human HEK293 cells expressing APP Swedish mutant assessed as reduction in amyloid beta 40 production after overnight incubatio...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed