BDBM50400781 CHEMBL2204997

SMILES CCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccc(nc1)N1CCN(C)CC1

InChI Key InChIKey=WCKDYPHUXUBMEB-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50400781   

TargetHistone-lysine N-methyltransferase EZH2(Human)
UNC Eshelman School of Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50400781BDBM50400781(CHEMBL2204997)
Affinity DataIC50: 10nMAssay Description:Inhibition of EZH2 methyltransferase activity (unknown origin) in PRC2 complex using 3H-SAM as substrate by Scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
UNC Eshelman School of Pharmacy

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50400781BDBM50400781(CHEMBL2204997)
Affinity DataIC50: 79nMAssay Description:Inhibition of EZH2-mediated proliferation of human LNCaP cells after 6 days by chemiluminescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed