BDBM50401549 CHEMBL2207081

SMILES Clc1ccc(Cn2ccnn2)c(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)c1

InChI Key InChIKey=YGWURLOZYUXZKA-UHFFFAOYSA-N

Data  7 KI  5 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50401549   

TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)
Affinity DataKi:  10nMAssay Description:Binding affinity to CCR2 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)
Affinity DataKi:  10nMAssay Description:Binding affinity to human CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)
Affinity DataKi:  79.4nMAssay Description:Antagonist activity at CCR2 assessed as inhibition of CCL2-stimulated THP-1 cell chemotaxis in presence of 0.1% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)
Affinity DataKi:  100nMAssay Description:Antagonist activity at CCR2 assessed as inhibition of CCL2-stimulated THP-1 cell chemotaxis in presence of 1% human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)
Affinity DataKi:  398nMAssay Description:Binding affinity to CCR1 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)
Affinity DataKi:  398nMAssay Description:Binding affinity to CCR4 by 35S-gamma-GTP membrane assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Mus musculus)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)
Affinity DataKi: >2.00E+3nMAssay Description:Binding affinity to murine CCR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)
Affinity DataIC50: >5.01E+4nMAssay Description:Inhibition of cytochrome P450 2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)
Affinity DataIC50:  200nMAssay Description:Inhibition of cytochrome P450 2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)
Affinity DataKd:  1.00E+4nMAssay Description:Antagonist activity at CCR2 in human whole blood assessed as inhibition of CCL2-stimulated monocyte shape changeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)
Affinity DataIC50:  3.98E+3nMAssay Description:Inhibition of cytochrome P450 3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)
Affinity DataIC50:  631nMAssay Description:Inhibition of cytochrome P450 2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50401549(CHEMBL2207081)
Affinity DataIC50: >5.01E+4nMAssay Description:Inhibition of cytochrome P450 1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed