BDBM50412984 CHEMBL458002

SMILES Cc1ccc(Cn2ncc(N3CCNCC3)c(Cl)c2=O)cc1NC(=O)c1ccc(cc1)-c1ccccc1

InChI Key InChIKey=ADETWEPXXIGKFW-UHFFFAOYSA-N

Data  10 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50412984   

Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50412984(CHEMBL458002)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]ketanserin from 5HT2A receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2C(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50412984(CHEMBL458002)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]mesulergine from 5HT2C receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50412984(CHEMBL458002)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]5HT from 5HT2B receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50412984(CHEMBL458002)
Affinity DataKi:  562nMAssay Description:Displacement of [3H]prazosin from adrenergic Alpha-1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1D(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50412984(CHEMBL458002)
Affinity DataKi:  741nMAssay Description:Displacement of [3H]5HT from 5HT1D receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50412984(CHEMBL458002)
Affinity DataKi:  776nMAssay Description:Displacement of [125I]iodosulpiride from dopamine D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1B(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50412984(CHEMBL458002)
Affinity DataKi:  776nMAssay Description:Displacement of [3H]5HT from 5HT1B receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50412984(CHEMBL458002)
Affinity DataKi:  832nMAssay Description:Displacement of [3H]LSD from 5HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50412984(CHEMBL458002)
Affinity DataKi:  2.40E+3nMAssay Description:Displacement of [125I]iodocyanopindolol from adrenergic beta2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50412984(CHEMBL458002)
Affinity DataKi:  4.90E+3nMAssay Description:Displacement of [125I]iodosulpiride from dopamine D2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMas-related G-protein coupled receptor member X1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50412984(CHEMBL458002)
Affinity DataEC50:  4.07E+3nMAssay Description:Agonist activity at human MrgX1 receptor expressed in HEK293 cells assessed as intracellular calcium mobilization by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed