BDBM50426967 CHEMBL2325079::PF-4693627
SMILES OC[C@H]1CCC[C@@H](C1)NC(=O)C1CCN(CC1)c1nc2cc(Cl)c(cc2o1)-c1ccc(Cl)cc1
InChI Key InChIKey=CPDNPVKDQXLYHO-JXFKEZNVSA-N
Data 11 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50426967
Affinity DataIC50: 3nMAssay Description:Inhibition of mPGES-1 (unknown origin) using PGH2 as substrate assessed as PGE2 synthesis by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 180nMAssay Description:Inhibition of mPGES-1 in human 1483 cells assessed as eicosanoid level incubated for 15 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of mPGES-1 in human fetal fibroblast cells assessed as PGF2alpha level after 50 mins by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 109nMAssay Description:Inhibition of mPGES-1-mediated PGE2 production in LPS-stimulated healthy human whole blood after 20 to 24 hrs by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of 5-LOX in human 1483 cells assessed as eicosanoid level incubated for 15 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of mPGES-1 activity in IL-1beta stimulated human A549 cells microsomes assessed as reduction in PGE2 production preincubated for 15 mins f...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of PGDS in human 1483 cells assessed as eicosanoid level incubated for 15 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of mPGES1 mediated PGE2 production in LPS-stimulated human whole blood by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of human mPGES1 by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 520nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as reduction in IL-1beta stimulated PGE2 production incubated for 24 hrs by EIAMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of TXAS in human 1483 cells assessed as eicosanoid level incubated for 15 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair