BDBM50431381 FOSTAMATINIB::R-788 Free acid::R-935788 Free acid

SMILES COc1cc(Nc2ncc(F)c(Nc3ccc4OC(C)(C)C(=O)N(COP(O)(O)=O)c4n3)n2)cc(OC)c1OC

InChI Key InChIKey=GKDRMWXFWHEQQT-UHFFFAOYSA-N

Data  6 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50431381   

TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50431381(FOSTAMATINIB | R-788 Free acid | R-935788 Free aci...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant truncated SYK (360 to 365 amino acid residues) using N-terminally biotinylated EPEGDYEEVLE peptide as substrate asses...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50431381(FOSTAMATINIB | R-788 Free acid | R-935788 Free aci...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Homo sapiens (Human))
Federal University Of Parana

Curated by ChEMBL
LigandPNGBDBM50431381(FOSTAMATINIB | R-788 Free acid | R-935788 Free aci...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human ABCG2 expressing membrane vesicles assessed inhibition of BCRP- mediated transport of [3H]estrone 3-sulfate for 2 mins using [3H]...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50431381(FOSTAMATINIB | R-788 Free acid | R-935788 Free aci...)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of SYK in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50431381(FOSTAMATINIB | R-788 Free acid | R-935788 Free aci...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50431381(FOSTAMATINIB | R-788 Free acid | R-935788 Free aci...)
Affinity DataIC50:  267nMAssay Description:Inhibition of SYK in human Ramos cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed