BDBM50434353 CHEMBL2386747::US9446044, 72

SMILES COC(=N)c1nc2ccc3ncnc(Nc4ccc(Cl)cc4Cl)c3c2s1

InChI Key InChIKey=QSGKPYRFWJINEH-UHFFFAOYSA-N

Data  26 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 26 hits for monomerid = 50434353   

TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Diaxonhit

US Patent
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  0.220nMpH: 7.5 T: 2°CAssay Description:The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Louisiana At Lafayette

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  221nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Diaxonhit

US Patent
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of recombinant DYRK1A (unknown origin) after 120 mins in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of recombinant DYRK1B (unknown origin) after 120 mins in presence of [33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Diaxonhit

US Patent
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of human DYRK1A using [33P]-ATP incubated for 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of human DYRK1B using [33P]-ATP incubated for 120 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Diaxonhit

US Patent
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of DYRK1B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  11nMAssay Description:Inhibition of DYRK2 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  93nMAssay Description:Inhibition of DYRK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  23nMAssay Description:Inhibition of CLK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  89nMAssay Description:Inhibition of CLK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK3(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CLK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK4(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  59nMAssay Description:Inhibition of CLK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of GSK3A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
University Of Louisiana At Lafayette

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  221nMAssay Description:Inhibition of GSK3B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Diaxonhit

US Patent
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
University Of Louisiana At Lafayette

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  23nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  0.280nMAssay Description:Inhibition of DYRK1B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  11nMAssay Description:Inhibition of DYRK2 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  93nMAssay Description:Inhibition of DYRK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
University Of Louisiana At Lafayette

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  89nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 3(Homo sapiens (Human))
University Of Louisiana At Lafayette

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CDK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
University Of Louisiana At Lafayette

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  59nMAssay Description:Inhibition of CDK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
University Of Oxford

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of GSK3alpha (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1B(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50434353(CHEMBL2386747 | US9446044, 72)
Affinity DataIC50:  0.280nMpH: 7.5 T: 2°CAssay Description:The DYRK1A and DYRK1B kinase assays to determine IC50 values were performed by Reaction Biology Corporation using HotSpot technology Worldwide websit...More data for this Ligand-Target Pair
In DepthDetails US Patent