BDBM50443181 CHEMBL3086535

SMILES CN(C)Cc1ccc(cc1)C1CC1C(=O)Nc1nc2ccc(cc2s1)-c1cn[nH]c1

InChI Key InChIKey=WIUYFJQWJMBTCE-UHFFFAOYSA-N

Data  1 KI  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50443181   

TargetTyrosine-protein kinase ITK/TSK(Human)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50443181(CHEMBL3086535)
Affinity DataKi:  0.600nMAssay Description:Inhibition of full length GST-tagged ITK (unknown origin) using Ac-EFPIYDFLPAKKK-NH2 as substrate after 35 mins by LC/MS analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ITK/TSK(Human)
Evotec (Uk)

Curated by ChEMBL
LigandPNGBDBM50443181(CHEMBL3086535)
Affinity DataIC50:  89nMAssay Description:Inhibition of ITK in human Jurkat cells assessed as inhibition of PLC-gamma1 phosphorylation by immuno-detection assayMore data for this Ligand-Target Pair