BDBM50443828 CHEMBL3094412
SMILES CCCCCCC(Sc1nc(Cl)cc(Nc2nc(cs2)-c2ccc3ccccc3c2)n1)C(O)=O
InChI Key InChIKey=BADFIDKPYNKNRT-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50443828
Affinity DataIC50: 300nMAssay Description:Inhibition of 5-LOX in human PMNL cells assessed as reduction in 5-LOX product formation pre-incubated for 15 mins by HPLC based cell-free assayMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of 5-LOX in human PMNL cells assessed as reduction in 5-LOX product formation pre-incubated for 15 mins by HPLC methodMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of mPGES-1 in human A549 cells microsomes assessed as reduction in PGE2 formation by RP-HPLC assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt
Curated by ChEMBL
Goethe-University Frankfurt
Curated by ChEMBL
Affinity DataEC50: 1.30E+3nMAssay Description:Activation of human PPARgamma ligand binding domain expressed in COS7 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of mPGES-1 from human A549 cell microsomal membranes using PGH2 as substrate incubated 15 mins prior to substrate addition measured after ...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant 5-lipoxygenase expressed in Escherichia coli BL21 using arachidonic acid as substrate incubated 5 to 10 mins prior to...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of 5-lipoxygenase in A23187-stimulated human polymorphonuclear leukocytes using arachidonic acid as substrate incubated 15 mins prior to s...More data for this Ligand-Target Pair