BDBM50443828 CHEMBL3094412

SMILES CCCCCCC(Sc1nc(Cl)cc(Nc2nc(cs2)-c2ccc3ccccc3c2)n1)C(O)=O

InChI Key InChIKey=BADFIDKPYNKNRT-UHFFFAOYSA-N

Data  6 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50443828   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443828BDBM50443828(CHEMBL3094412)
Affinity DataIC50: 200nMAssay Description:Inhibition of 5-LOX in human PMNL cells assessed as reduction in 5-LOX product formation pre-incubated for 15 mins by HPLC methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2016
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443828BDBM50443828(CHEMBL3094412)
Affinity DataIC50: 300nMAssay Description:Inhibition of 5-LOX in human PMNL cells assessed as reduction in 5-LOX product formation pre-incubated for 15 mins by HPLC based cell-free assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2016
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443828BDBM50443828(CHEMBL3094412)
Affinity DataIC50: 400nMAssay Description:Inhibition of mPGES-1 in human A549 cells microsomes assessed as reduction in PGE2 formation by RP-HPLC assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2016
Entry Details Article
PubMed
TargetPeroxisome proliferator-activated receptor gamma(Human)
Goethe-University Frankfurt

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50443828BDBM50443828(CHEMBL3094412)
Affinity DataEC50:  1.30E+3nMAssay Description:Activation of human PPARgamma ligand binding domain expressed in COS7 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2016
Entry Details Article
PubMed