BDBM50445222 CHEMBL3105228
SMILES Fc1ccc(cc1F)C(=O)N1CCN2C(=O)c3ccccc3[C@@]12c1ccc(Cl)cc1
InChI Key InChIKey=GXBAKXRLQAPKEE-UHFFFAOYSA-N
Data 12 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 12 hits for monomerid = 50445222
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate preincubated for 15 mins followed by NADPH addition measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 7.40E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate preincubated for 15 mins followed by NADPH addition measured after 8 min...More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate preincubated for 15 mins followed by NADPH addition measured after 8 min...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Negative allosteric modulation of rat muscarinic acetylcholine receptor M4 expressed in CHO cells assessed as inhibition of acetylcholine-induced cal...More data for this Ligand-Target Pair
Affinity DataIC50: 790nMAssay Description:Negative allosteric modulation of rat muscarinic acetylcholine receptor M5 expressed in CHO cells assessed as inhibition of acetylcholine-induced cal...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Human)
Vanderbilt University School of Medicine
Curated by ChEMBL
Vanderbilt University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.11E+3nMAssay Description:Negative allosteric modulation of human M5 receptor expressed in CHO cells assessed as inhibition of acetyl choline-induced calcium mobilization prei...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Human)
Vanderbilt University School of Medicine
Curated by ChEMBL
Vanderbilt University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.05E+3nMAssay Description:Negative allosteric modulation of human M5 receptor expressed in CHO cells assessed as inhibition of acetyl choline-induced calcium mobilization prei...More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human muscarinic M2 receptor assessed as inhibition of acetylcholine-induced calcium responseMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human muscarinic M3 receptor assessed as inhibition of acetylcholine-induced calcium responseMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human muscarinic M4 receptor assessed as inhibition of acetylcholine-induced calcium responseMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Antagonist activity at human muscarinic M1 receptor assessed as inhibition of acetylcholine-induced calcium responseMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M5(Human)
Vanderbilt University School of Medicine
Curated by ChEMBL
Vanderbilt University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Antagonist activity at human muscarinic M5 receptor assessed as inhibition of acetylcholine-induced calcium responseMore data for this Ligand-Target Pair