BDBM50458024 CHEMBL4203179

SMILES CCN1CCC(CC1)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1

InChI Key InChIKey=AUIRGOWAROZXCR-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50458024   

TargetCytochrome P450 2C8(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50458024(CHEMBL4203179)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes preincubated for 10 mins followed by NADPH/substrate addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50458024(CHEMBL4203179)
Affinity DataIC50:  66nMAssay Description:Inhibition of human CDK9/Cyclin-T1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50458024(CHEMBL4203179)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes preincubated for 10 mins followed by NADPH/substrate addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50458024(CHEMBL4203179)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes preincubated for 10 mins followed by NADPH/substrate addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50458024(CHEMBL4203179)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes preincubated for 10 mins followed by NADPH/substrate addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50458024(CHEMBL4203179)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes preincubated for 10 mins followed by NADPH/substrate addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50458024(CHEMBL4203179)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes preincubated for 10 mins followed by NADPH/substrate addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50458024(CHEMBL4203179)
Affinity DataIC50:  1.60nMAssay Description:Inhibition of human CDK6/Cyclin-D3More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50458024(CHEMBL4203179)
Affinity DataIC50:  1.18E+3nMAssay Description:Inhibition of human CDK1/Cyclin-B using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50458024(CHEMBL4203179)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by automated Q-patch methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50458024(CHEMBL4203179)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed