BDBM50458024 CHEMBL4203179
SMILES CCN1CCC(CC1)N1CCc2nc(Nc3ncc(F)c(n3)-c3cc(F)c4nc(C)n(C(C)C)c4c3)ccc2C1
InChI Key InChIKey=AUIRGOWAROZXCR-UHFFFAOYSA-N
Data 11 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50458024
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C8 in human liver microsomes preincubated for 10 mins followed by NADPH/substrate addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical
Curated by ChEMBL
Shanghai Haihe Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 66nMAssay Description:Inhibition of human CDK9/Cyclin-T1More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP1A2 in human liver microsomes preincubated for 10 mins followed by NADPH/substrate addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes preincubated for 10 mins followed by NADPH/substrate addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes preincubated for 10 mins followed by NADPH/substrate addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2B6 in human liver microsomes preincubated for 10 mins followed by NADPH/substrate addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes preincubated for 10 mins followed by NADPH/substrate addition by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical
Curated by ChEMBL
Shanghai Haihe Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human CDK6/Cyclin-D3More data for this Ligand-Target Pair
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical
Curated by ChEMBL
Shanghai Haihe Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of human CDK1/Cyclin-B using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical
Curated by ChEMBL
Shanghai Haihe Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human ERG expressed in CHO cells at -80 mV holding potential by automated Q-patch methodMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Homo sapiens (Human))
Shanghai Haihe Pharmaceutical
Curated by ChEMBL
Shanghai Haihe Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human CDK4/cyclin D1 using ULight-substrate after 1 hr by LANCE assayMore data for this Ligand-Target Pair