BDBM50464614 CHEMBL4277525::US11091476, Example 6

SMILES CC1=Nc2c(cc(cc2F)-c2nc(Nc3ccc(cn3)N3CCNCC3)ncc2F)C11CCCC1

InChI Key InChIKey=QNUFZYZRLJGZJL-UHFFFAOYSA-N

Data  17 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50464614   

TargetCyclin-A2/Cyclin-dependent kinase 1(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50:  152nMAssay Description:Inhibition of CDK1/Cyclin-A2 (unknown origin) using histone-H1 as substrate after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50:  15.1nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK6/Cyclin-D3 (unknown origin) using histoneH1 as substrate after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G1/S-specific cyclin- 2(Homo sapiens (Human))
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50:  152nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50:  6.45nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase/G1/S-specific cyclin- 2(Homo sapiens (Human))
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50:  152nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50:  6.45nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 1/G1/S-specific cyclin-D3(Homo sapiens (Human))
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50:  0.420nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase/G1/S-specific cyclin- 2(Homo sapiens (Human))
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50:  152nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50:  6.45nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 1/G1/S-specific cyclin-D3(Homo sapiens (Human))
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50:  0.420nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50:  15.1nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase/G1/S-specific cyclin- 2(Homo sapiens (Human))
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50:  152nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-E1(Homo sapiens (Human))
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50:  80.9nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 6/G1/S-specific cyclin-D3(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50:  6.45nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 1/G1/S-specific cyclin-D3(Homo sapiens (Human))
Gan & Lee Pharmaceuticals

US Patent
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50:  0.420nMAssay Description: 1.2.2 Preparation of kinase solution: Kinase solutions having the concentrations required for each reaction system were prepared from 100 ng/...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Beijing Normal University

Curated by ChEMBL
LigandPNGBDBM50464614(CHEMBL4277525 | US11091476, Example 6)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDK4/Cyclin-D1 (unknown origin) using histone-H1 as substrate after 90 mins by ADP-Glo assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed