BDBM50466375 CHEMBL4287674

SMILES CCS(=O)(=O)c1ccc(CC(=O)Nc2ccc(c(F)c2)C(C)(C)C(=O)Nc2ccc(F)cc2F)cc1

InChI Key InChIKey=DZUAIKQCQQBQJM-UHFFFAOYSA-N

Data  7 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50466375   

TargetNuclear receptor ROR-beta(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466375(CHEMBL4287674)
Affinity DataIC50: >1.00E+4nMAssay Description:Transrepression of recombinant human GAL4-DBD fused RORbeta LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466375(CHEMBL4287674)
Affinity DataEC50: >3.00E+4nMAssay Description:Transrepression of recombinant human GAL4-DBD fused LXRbeta LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466375(CHEMBL4287674)
Affinity DataIC50:  200nMAssay Description:Transrepression of RORgammat in anti-CD3/CD28 stimulated C57BL/6 mouse CD4-positive T cells assessed as suppression of T cell differentiation to Th17...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466375(CHEMBL4287674)
Affinity DataIC50:  13nMAssay Description:Transrepression of RORgammat in anti-CD3/CD28 stimulated human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466375(CHEMBL4287674)
Affinity DataEC50: >3.00E+4nMAssay Description:Transrepression of recombinant human GAL4-DBD fused LXRalpha LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466375(CHEMBL4287674)
Affinity DataIC50: <30nMAssay Description:Displacement of [3H]-Digoxin from recombinant human GST-fused RORgammat LBD after 1 to 4 hrs by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-alpha(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466375(CHEMBL4287674)
Affinity DataIC50: >1.00E+4nMAssay Description:Displacement of [3H]T0901317 from recombinant human GST-fused RORalpha LBD after 1 to 4 hrs by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Mus musculus)
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466375(CHEMBL4287674)
Affinity DataIC50:  340nMAssay Description:Transrepression of recombinant mouse GAL4-DBD fused RORgammat LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Shionogi

Curated by ChEMBL
LigandPNGBDBM50466375(CHEMBL4287674)
Affinity DataIC50:  29nMAssay Description:Transrepression of recombinant human GAL4-DBD fused RORgammat LBD expressed in HEK293 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed